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RNA interference in functional genomics and medicine

Cited 39 time in Web of Science Cited 45 time in Scopus
Authors
Kim, V. Narry
Issue Date
2003-06
Citation
Journal of Korean Medical Science, Vol.18 No.3, pp.309-318
Keywords
RNA interference (RNAi)RNA, small interfering (siRNA)microRNAs (miRNA)small hairpin RNA (shRNA)mRNA degradationtranslationfunctional genomicsgene therapy
Abstract
RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional genomics but also holds a promise for gene therapy. The key player in RNAi is small RNA (similar to22-nt) termed siRNA. Small RNAs are involved not only in RNAi but also in basic cellular processes, such as developmental control and heterochromatin formation. The interesting biology as well as the remarkable technical value has been drawing widespread attention to this exciting new field.
ISSN
1011-8934
URI
https://hdl.handle.net/10371/171914
DOI
https://doi.org/10.3346/jkms.2003.18.3.309
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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