S-Space College of Natural Sciences (자연과학대학) Dept. of Biological Sciences (생명과학부) Journal Papers (저널논문_생명과학부)
RNA interference in functional genomics and medicine
- Kim, V. Narry
- Issue Date
- Journal of Korean Medical Science, Vol.18 No.3, pp.309-318
- RNA interference (RNAi); RNA, small interfering (siRNA); microRNAs (miRNA); small hairpin RNA (shRNA); mRNA degradation; translation; functional genomics; gene therapy
- RNA interference (RNAi) is the sequence-specific gene silencing induced by double-stranded RNA (dsRNA). Being a highly specific and efficient knockdown technique, RNAi not only provides a powerful tool for functional genomics but also holds a promise for gene therapy. The key player in RNAi is small RNA (similar to22-nt) termed siRNA. Small RNAs are involved not only in RNAi but also in basic cellular processes, such as developmental control and heterochromatin formation. The interesting biology as well as the remarkable technical value has been drawing widespread attention to this exciting new field.
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