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Graphene quantum dots prevent α-synucleinopathy in Parkinsons disease

Cited 96 time in Web of Science Cited 107 time in Scopus
Authors
Kim, Donghoon; Yoo, Je Min; Hwang, Heehong; Lee, Junghee; Lee, Su Hyun; Yun, Seung Pil; Park, Myung Jin; Lee, MinJun; Choi, Seulah; Kwon, Sang Ho; Lee, Saebom; Kwon, Seung-Hwan; Kim, Sangjune; Park, Yong Joo; Kinoshita, Misaki; Lee, Young-Ho; Shin, Seokmin; Paik, Seung R.; Lee, Sung Joong; Lee, Seulki; Hong, Byung Hee; Ko, Han Seok
Issue Date
2018-09
Citation
Nature Nanotechnology, Vol.13 No.9, pp.812-818
Abstract
Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation(1,2) and transmission(3,4) of alpha-synuclein (alpha-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic. Here, we show that graphene quantum dots (GQDs) inhibit fibrillization of alpha-syn and interact directly with mature fibrils, triggering their disaggregation. Moreover, GQDs can rescue neuronal death and synaptic loss, reduce Lewy body and Lewy neurite formation, ameliorate mitochondrial dysfunctions, and prevent neuron-to-neuron transmission of alpha-syn pathology provoked by alpha-syn preformed fibrils(5,6). We observe, in vivo, that GQDs penetrate the blood-brain barrier and protect against dopamine neuron loss induced by alpha-syn preformed fibrils, Lewy body/Lewy neurite pathology and behavioural deficits.
ISSN
1748-3387
URI
https://hdl.handle.net/10371/172251
DOI
https://doi.org/10.1038/s41565-018-0179-y
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
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