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Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Lee, Ah Young; Kim, Sang Wha; Lee, Somin; Jiang, Hu-Lin; Kim, Sang-Bum; Hong, Seong-Ho; Cho, Myung-Haing
Issue Date
2017-05
Citation
Anticancer Research, Vol.37 No.5, pp.2381-2386
Keywords
Lung canceraerosol deliverygene therapyimportin 7GPT-SPE
Abstract
Background/Aim: Lung cancer shows the highest estimated deaths in both males and females in the Unites States. Importin 7 is overexpressed in lung adenocarcinoma tissues. In this study, we aimed to demonstrate the anticancer effect of importin 7 down-regulation, especially in lung cancer. Materials and Methods: Glycerol propoxylate triacrylate spermine (GPT-SPE) is a biocompatible carrier used for aerosol gene delivery. Repeated aerosol delivery of GPT-SPE/shImportin 7 complexes was performed to 10-week-old male K-ras(LA1) mice (a murine lung cancer model) twice a week for 4 weeks (8 times) in a nose-only exposure chamber. Results: Aerosol delivery of GPT-SPE/shImportin 7 inhibits lung cancer in K-ras(LA1) mice compared to control and scramble control groups. Moreover, importin 7-down-regulated stable cell-line demonstrates suppression of proliferation through Akt inhibition and apoptosis. Conclusion: Down-regulation of importin 7 significantly suppresses lung cancer in vitro and in vivo.
ISSN
0250-7005
URI
https://hdl.handle.net/10371/172298
DOI
https://doi.org/10.21873/anticanres.11576
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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