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Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models

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Authors
Baek, SW; Kim, NK; Jin, HJ; Koh, CW; Kim, CK; Kwon, OH; Kim, JS; Cho, Myung-Haing; Park, CK
Issue Date
2005
Citation
Arzneimittel-Forschung/Drug Research, Vol.55 No.8, pp.461-465
Keywords
Anti-ulcer drugCAS 554-62-1phytosphingosine hydrochloride, anti-ulcer action, rat
Abstract
The gastroprotective activity of phytosphingosine hydrochloride (PS-HCI, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCI/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCI (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCI/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer.
ISSN
0004-4172
URI
https://hdl.handle.net/10371/172312
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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