S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models
- Baek, SW; Kim, NK; Jin, HJ; Koh, CW; Kim, CK; Kwon, OH; Kim, JS; Cho, Myung-Haing; Park, CK
- Issue Date
- Arzneimittel-Forschung/Drug Research, Vol.55 No.8, pp.461-465
- The gastroprotective activity of phytosphingosine hydrochloride (PS-HCI, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCI/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCI (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCI/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer.
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