S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
FCHO1560−571 peptide, a PKB kinase motif, inhibits tumor progression
- Park, Sungjin; Hong, Youngeun; Lee, Soomin; Lee, Ah Young; Tran, Quangdon; Lee, Hyunji; Kim, Minhee; Park, Jisoo; Cho, Myung-Haing; Park, Jongsun
- Issue Date
- Biochemical and Biophysical Research Communications, Vol.528 No.3, pp.478-484
- Background: Cell division is regulated by protein kinase B (PKB)-mediated FCH domain only 1 (FCHO1) phosphorylation. Methods: FCHO1560-571, a synthetic water-soluble peptide, was generated from the PKB substrate motif 560PPRRLRSRKVSC571 found in the human FCHO1 protein. Results: In this study, we found that in vitro FCHO1560-571 inhibits cell proliferation via PKB/ERK/SMAD4 pathways in KRAS-mutated A549 lung cancer cells. In addition, FCHO1560-571, at effective doses of 15 and 30 mg/kg, significantly suppressed tumor growth and decreased the size and weight of tumors in A549xenograft mice. Conclusion: These results suggest that the FCHO1560-571 peptide could be a potential therapy for lung cancer. (C) 2020 Elsevier Inc. All rights reserved.
- Files in This Item: There are no files associated with this item.