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FCHO1560−571 peptide, a PKB kinase motif, inhibits tumor progression

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Authors
Park, Sungjin; Hong, Youngeun; Lee, Soomin; Lee, Ah Young; Tran, Quangdon; Lee, Hyunji; Kim, Minhee; Park, Jisoo; Cho, Myung-Haing; Park, Jongsun
Issue Date
2020-07
Citation
Biochemical and Biophysical Research Communications, Vol.528 No.3, pp.478-484
Keywords
Cell-penetrating peptideWater-soluble peptideFCHO1PKBSMAD4Lung cancer
Abstract
Background: Cell division is regulated by protein kinase B (PKB)-mediated FCH domain only 1 (FCHO1) phosphorylation. Methods: FCHO1560-571, a synthetic water-soluble peptide, was generated from the PKB substrate motif 560PPRRLRSRKVSC571 found in the human FCHO1 protein. Results: In this study, we found that in vitro FCHO1560-571 inhibits cell proliferation via PKB/ERK/SMAD4 pathways in KRAS-mutated A549 lung cancer cells. In addition, FCHO1560-571, at effective doses of 15 and 30 mg/kg, significantly suppressed tumor growth and decreased the size and weight of tumors in A549xenograft mice. Conclusion: These results suggest that the FCHO1560-571 peptide could be a potential therapy for lung cancer. (C) 2020 Elsevier Inc. All rights reserved.
ISSN
0006-291X
URI
https://hdl.handle.net/10371/172322
DOI
https://doi.org/10.1016/j.bbrc.2020.05.173
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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