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Suppression of tumor growth in xenograft model mice by programmed cell death 4 gene delivery using folate-PEG-baculovirus

Cited 12 time in Web of Science Cited 15 time in Scopus
Authors
Kim, Y-K; Kwon, J-T; Choi, J. Y.; Jiang, H-L; Arote, R.; Jere, D.; Je, Y. H.; Cho, Myung-Haing; Cho, C-S
Issue Date
2010-11
Citation
Cancer Gene Therapy, Vol.17 No.11, pp.751-760
Keywords
baculovirusprogrammed cell death 4apoptosis
Abstract
Cancer gene therapy using tumor suppressor genes is considered to be an attractive approach for arresting cell growth and inducing apoptosis. Programmed cell death 4 (Pdcd4) is a tumor suppressor gene, which prevents tumorigenesis and tumor progression. To address the issue of whether expression of PDCD4 protein induces apoptosis in cancerous cells, the Pdcd4 gene was delivered using folate-PEG-baculovirus. Folate-PEG-baculovirus containing Pdcd4 gene (F-P-Bac-Pdcd4) was constructed by attachment of F-PEG to the baculovirus surface using chemical modification. The F-P-Bac-Pdcd4 showed enhanced transduction efficiency, efficiently expressed PDCD4 protein, and induced apoptosis in human epidermal carcinoma (KB) cells as compared with an unmodified baculovirus. In a tumor xenograft study, injection of F-P-Bac-Pdcd4 into tumors established from the KB cell line by subcutaneous implantation significantly suppressed tumor growth and induced apoptosis. Thus, this study shows a new baculovirus-mediated tumor suppressor gene delivery system for cancer therapy. Cancer Gene Therapy (2010) 17, 751-760; doi:10.1038/cgt.2010.28; published online 11 June 2010
ISSN
0929-1903
URI
https://hdl.handle.net/10371/172350
DOI
https://doi.org/10.1038/cgt.2010.28
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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