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Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells

Cited 32 time in Web of Science Cited 40 time in Scopus
Authors
Xu, Cheng-Xiong; Jin, Hua; Chung, Youn-Sun; Shin, Ji-Young; Woo, Min-Ah; Lee, Kee-Ho; Palmos, Grace N.; Choi, Byeong-Dae; Cho, Myung-Haing
Issue Date
2008-06
Citation
Cancer Letters, Vol.264 No.1, pp.93-100
Keywords
Styela clava tunicchondroitin sulfateiNOSVCAM-1NF-kappa Bakt
Abstract
Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172354
DOI
https://doi.org/10.1016/j.canlet.2008.01.022
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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