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Degradable polyethylenimines as DNA and small interfering RNA carriers

Cited 93 time in Web of Science Cited 87 time in Scopus
Authors
Jere, D.; Jiang, H. L.; Arote, R.; Kim, Y. K.; Choi, Y. J.; Cho, Myung-Haing; Akaike, T.; Chot, C. S.
Issue Date
2009-08
Citation
Expert Opinion on Drug Delivery, Vol.6 No.8, pp.827-834
Keywords
degradable polyethylenimineDNA deliverygene therapysiRNA delivery
Abstract
Gene therapy is a powerful approach in the treatment of a wide range of both inherited and acquired diseases. Nonviral delivery systems have been proposed as safer alternatives to viral vectors because they avoid the inherent immunogenicity and production problems that are seen when viral systems are used. Many cationic polymers, including high-molecular-weight polyethylenimine (PEI) have been widely studied as gene-delivery carriers, both, in vitro and in vivo. However, interest has recently developed in degradable polymeric systems. The advantage of degradable polymer is its low in-vivo cytotoxicity, which is a result of its easy elimination from the cells and body. Degradable polymer also enhances transfection of DNA or small interfering RNA (siRNA) for efficient gene expression or silencing, respectively. This review paper summarizes and discusses the recent advances with degradable PEIs, such as cross-linked and grafted PEIs for DNA and siRNA delivery.
ISSN
1742-5247
URI
https://hdl.handle.net/10371/172378
DOI
https://doi.org/10.1517/17425240903029183
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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