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Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse

Cited 10 time in Web of Science Cited 20 time in Scopus
Authors
Hwang, Soon-Kyung; Minai-Tehrani, Arash; Lim, Hwang-Tae; Shin, Ji-Young; An, Gil-Hwan; Lee, Kee-Ho; Park, Kee-Rang; Kim, Yeon-Soo; Beck, George R., Jr.; Yang, Hsin-Sheng; Cho, Myung-Haing
Issue Date
2010-10
Citation
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol.23 No.5, pp.285-293
Keywords
aerosol gene deliveryshRNA Pdcd4lung cell proliferation
Abstract
Background: Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumor suppressor gene in human cancer. The majority of tumor suppressors are mutationally inactivated, but the expression of Pdcd4 is downregulated with progression in a number of human cancer sites, including the lung. Methods: An aerosol of lentivirus-shRNA Pdcd4 was delivered into A/J mice, through a nose-only inhalation system twice a week for 1 month. Results and Conclusions: Downregulated Pdcd4 resulted in increase levels of antiapoptotic and uPA-regulated proteins. We also found that downregulated Pdcd4 induced the mTOR/p70S6K pathway and cell-cycle proteins. Our results suggest that Pdcd4 may perform a critical function in the regulation of lung cancer cell proliferation.
ISSN
1941-2711
URI
https://hdl.handle.net/10371/172409
DOI
https://doi.org/10.1089/jamp.2009.0778
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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