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Biodegradable Nano-Polymeric System for Efficient Akt1 siRNA Delivery

Cited 18 time in Web of Science Cited 18 time in Scopus
Authors
Jere, Dhananjay; Arote, Rohidas; Jiang, Hu-Lin; Kim, You-Kyoung; Cho, Myung-Haing; Cho, Chong-Su
Issue Date
2010-05
Citation
Journal of Nanoscience and Nanotechnology, Vol.10 No.5, pp.3366-3369
Keywords
siRNA DeliveryNonviral VectorsPolycaprolactonePolymeric CarrierLung CancerAkt1 ProteinNanocarriersGene Delivery
Abstract
Biodegradable nano-polymeric carrier composed of polycaprolactone (PCL) and polyethylenimine (PEI) (BNPP) was successfully synthesized for the delivery of sh/siRNA in lung cancer cells. BNPP efficiently and safely delivered siRNA in lung cancer cells. BNPP-delivered Akt1 siRNA silenced Akt1 protein, and reduced the cancer cell survival, proliferation, malignancy and metastasis.
ISSN
1533-4880
URI
https://hdl.handle.net/10371/172440
DOI
https://doi.org/10.1166/jnn.2010.2228
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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