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Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation

Cited 50 time in Web of Science Cited 53 time in Scopus
Authors
Kim, Jun Sung; Kim, Young-Hwa; Kim, Jin Hyun; Kang, Keon Wook; Tae, Eunju Lee; Youn, Hyewon; Kim, Daehong; Kim, Seok-Ki; Kwon, Jung-Taek; Cho, Myung-Haing; Lee, Yun-Sang; Jeong, Jae Min; Chung, June-Key; Lee, Dong Soo
Issue Date
2012-02
Citation
Nanomedicine, Vol.7 No.2, pp.219-229
Keywords
magnetic resonance imagingmagnetic silica nanoparticlesmultimodal in vivo imagingnear-infrared fluorescencepositron emission tomography
Abstract
Aim: To monitor cells in vivo or to detect the sentinel lymph node, we developed a PET/MRI silica nanoprobe with an enhanced near-infrared fluorescence signal. Methods: We developed enhanced near-infrared fluorescent (NIRF) magnetic silica nanoparticles, MNP-SiO2(NIR797), that encapsulate NIRF dye in the silica. We applied this probe to visualizing cells in the deep tissue of mice using NIRF imaging. After labeling with a radioisotope, Ga-68, on the surface of MNP-SiO2(NIR797), we injected it into the forepaw of mice to visualize the sentinel lymph node. Results: This encapsulated nanoprobe showed enhancement of fluorescent intensity and stability compared with the nanoprobe, which had the same dyes on the surface of the silica nanoparticles. We also obtained multimodal in vivo imaging of Ga-68-{MNP-SiO2(NIR797)} applied to sentinel lymph node detection of mice using PET/MRI/NIRF images. Conclusion: This multimodal nanoprobe with enhanced fluorescence may provide a useful tool for imaging diagnostics and cell tracking.
ISSN
1743-5889
URI
https://hdl.handle.net/10371/172480
DOI
https://doi.org/10.2217/NNM.11.94
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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