S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Inhibitors of 5 alpha-reductase type I in LNCaP cells from the roots of Angelica koreana
- Seo, Eun-Kyoung; Kim, Kyeong Ho; Kim, Min Ki; Cho, Myung-Haing; Choi, Eunwook; Kim, Kinam; Mar, Woong Chon
- Issue Date
- Planta Medica, Vol.68 No.2, pp.162-163
- A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5alpha-reductase type I inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5alpha-reductase type I in LNCaP cells with an IC50 value of 0.1 mug/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 mug/ml). Bisabolangelone also inhibited the activity of 5alpha-reductase type I in LNCaP cells (IC50 = 11.6 mug/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5 a-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5alpha-reductase assay systems used in the present study.
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