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The simplest flowchart stating the mechanisms for organic xenobiotics-induced toxicity: Can it possibly be accepted as a central dogma for toxic mechanisms?

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Authors
Park, Yeong-Chul; Lee, Sundong; Cho, Myung-Haing
Issue Date
2014-09
Citation
한국독성학회지, Vol.30 No.3, pp.179-184
Keywords
BiotransformationCytochrome P450ReactivationReactive intermediatesReversibility vs. irreversibilityToxicokinetics vs. toxicodynamics
Abstract
Xenobiotics causing a variety of toxicity in biological systems could be classified as two types, inorganic and organic chemicals. It is estimated that the organic xenobiotics are responsible for approximately 80~90% of chemical-induced toxicity in human population. In the class for toxicology, we have encountered some difficulties in explaining the mechanisms of toxicity caused especially by organic chemicals. Here, a simple flowchart was introduced for explaining the mechanism of toxicity caused by organic xenobiotics, as the central dogma of molecular biology. This flowchart, referred to as a central dogma, was described based on a view of various aspects as follows: direct-acting chemicals vs. indirect-acting chemicals, cytochrome P450-dependent vs. cytochrome P450-independent biotransformation, reactive intermediates, reactivation, toxicokinetics vs. toxicodynamics, and reversibility vs. irreversibility. Thus, the primary objective of this flowchart is to help better understanding of the organic xenobiotics-induced toxic mechanisms, providing a major pathway for toxicity occurring in biological systems.
ISSN
1976-8257
URI
https://hdl.handle.net/10371/172540
DOI
https://doi.org/10.5487/TR.2014.30.3.179
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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