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Resveratrol suppresses migration, invasion and sternness of human breast cancer cells by interfering with tumor-stromal cross-talk

Cited 25 time in Web of Science Cited 28 time in Scopus
Authors
Suh, Jinyoung; Kim, Do-Hee; Surh, Young-Joon
Issue Date
2018-04
Citation
Archives of Biochemistry and Biophysics, Vol.643, pp.62-71
Keywords
Breast cancerCancer-associated fibroblastsCancer stem cellsResveratrolTumor microenvironment
Abstract
Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs produce a variety of cytokines, growth factors and extracellular matrix proteins, thereby stimulating tumor progression. CAFs are distinct from normal fibroblasts for their overexpression of a-smooth muscle actin. Recent studies suggest that CAFs play an important role in proliferation and migration of cancer cells through cross-talk with them. Resveratrol (trans-3,4'5,-trihydroxystilbene), a phytoalexin present in grapes, has been reported to possess chemopreventive and chemotherapeutic activities. In the present study, we examined the effects of resveratrol on CAF-induced migration, invasion and self-renewal activity of breast cancer cells. Resveratrol inhibited proliferation, migration and invasion of human breast cancer cells treated with CAF-conditioned media (CAF-CM). Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9. In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Further, resveratrol abrogated stemness properties and reduced the expression of self-renewal signaling molecules in stem-like breast cancer cells. Taken together, the present study provides insights into the role of resveratrol in tumor microenvironment with focus on interaction between cancer cells and the hosting niche.
ISSN
0003-9861
URI
https://hdl.handle.net/10371/172571
DOI
https://doi.org/10.1016/j.abb.2018.02.011
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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