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Suppression of phorbol ester-induced NF-κB activation by capsaicin in cultured human promyelocytic leukemia cells

Cited 35 time in Web of Science Cited 39 time in Scopus
Authors
Han, Seong-Su; Keum, Young-Sam; Chun, Kyung-Soo; Surh, Young-Joon
Issue Date
2002-08
Citation
Archives of Pharmacal Research, Vol.25 No.4, pp.475-479
Keywords
activator protein-1 (AP-1)capsaicinHL-60 cellsNF-kappa BTPA
Abstract
Capsaicin, a major pungent constituent of red pepper (Capsicum annuum L.) possesses a vast variety of pharmacologic and physiologic activities. Despite its irritant properties, the compound exerts anti-inflammatory and anti-nociceptive effects. Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin. In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaBalpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells. Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding. Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment.
ISSN
0253-6269
URI
https://hdl.handle.net/10371/172581
DOI
https://doi.org/10.1007/BF02976605
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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