S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Modulation by nitric oxide (NO) of capsaicin-induced calcium uptake into rat dorsal root ganglion neurons
- Park, Young‐Ho; Surh, Young‐Joon; Lee, Sang‐Sup
- Issue Date
- Biochemistry and Molecular Biology International, Vol.47 No.3, pp.435-442
- The regulatory role of nitric oxide in capsaicin-induced Ca-45(2+) accumulation in dorsal root ganglion neuronal cultures was investigated. Capsaicin-activated calcium entry was subject to complicated tuning by NO-releasing agents sodium nitroprusside, spermine/NO complex and NO synthase inhibitor N-G-nitro-L-arginine methyl ester in concentration and stimulation protocol-dependent manner. In contrast, these agents failed to change depolarization-induced calcium influx. Tn experiments using dithiothreitol and 5,5-dithio-bis-2-nitrobenzoic acid this modulation was independent of the oxidizing action of NO. It is suggested that NO exerts a novel feedback modulatory effects on capsaicin-induced calcium entry into rat DRG neurons.
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