S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Dual roles of pin1 in cancer development and progression
- Han, Hyeong-Jun; Choi, Bu Young; Surh, Young-Joon
- Issue Date
- Current Pharmaceutical Design, Vol.23 No.29, pp.4422-4425
- Pin1; proline-directed protein kinases; phosphorylation-dependent peptidyl-prolyl isomerase; pSer/Thr-Pro motif; PPIase; proline isomerization
- Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.
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