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Dual roles of pin1 in cancer development and progression

Cited 8 time in Web of Science Cited 8 time in Scopus
Authors
Han, Hyeong-Jun; Choi, Bu Young; Surh, Young-Joon
Issue Date
2017-08
Citation
Current Pharmaceutical Design, Vol.23 No.29, pp.4422-4425
Keywords
Pin1proline-directed protein kinasesphosphorylation-dependent peptidyl-prolyl isomerasepSer/Thr-Pro motifPPIaseproline isomerization
Abstract
Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.
ISSN
1381-6128
URI
https://hdl.handle.net/10371/172685
DOI
https://doi.org/10.2174/1381612823666170703164711
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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