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Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation

Cited 17 time in Web of Science Cited 18 time in Scopus
Authors
Zhong, Xiancai; Lee, Ha-Na; Kim, Seung Hyeon; Park, Sin-Aye; Kim, Wonki; Cha, Young-Nam; Surh, Young-Joon
Issue Date
2018-10
Citation
FASEB Journal, Vol.32 No.10, pp.5312-5325
Keywords
c-Mycphagocytosisperitonitistubulin acetylation
Abstract
A key event required for effective resolution of inflammation is efferocytosis, which is defined as phagocytic removal of apoptotic cells mostly by macrophages acquiring an alternatively activated phenotype (M2). c-Myc has been reported to play a role in alternative activation of human macrophages and is proposed as one of the M2 macrophage markers. We found that M2-like peritoneal macrophages from zymosan A-treated mice exhibited a marked accumulation of Myc-nick, a truncated protein generated by a Calpain-mediated proteolytic cleavage of full-length c-Myc. Further, ectopic expression of Myc-nick in murine bone marrow-derived macrophages promoted the M2 polarization and, consequently, enhanced their efferocytic capability. Notably, Myc-nick-induced efferocytosis was found to be tightly associated with -tubulin acetylation by K acetyltransferase 2a (Kat2a/Gcn5) activity. These findings suggest Myc-nick as a novel proresolving mediator that has a fundamental function in maintaining homeostasis under inflammatory conditions.Zhong, X., Lee, H.-N., Kim, S. H., Park, S.-A., Kim, W., Cha, Y.-N., Surh, Y.-J. Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation.
ISSN
0892-6638
URI
https://hdl.handle.net/10371/172699
DOI
https://doi.org/10.1096/fj.201800223R
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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