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Janus-faced role of SIRT1 in tumorigenesis

Cited 115 time in Web of Science Cited 113 time in Scopus
Authors
Song, Na-Young; Surh, Young-Joon
Issue Date
2012-10
Citation
Annals of the New York Academy of Sciences, Vol.1271, pp.10-19
Keywords
SIRT1cancersubcellular localization
Abstract
Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has tumor-suppressor properties. On the other hand, SIRT1 can stimulate oncogenic signaling pathways and can create a tumor microenvironment favorable to growth and survival of cancer cells. Such dual functions of SIRT1 may be determined, at least in part, by its subcellular localization. Interestingly, SIRT1 displays differential localization in normal cells and cancer cells, which in turn may affect the substrate specificity for its deacetylase activity.
ISSN
0077-8923
URI
https://hdl.handle.net/10371/172705
DOI
https://doi.org/10.1111/j.1749-6632.2012.06762.x
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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