S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor
- Kang, Kyoung Ah; Lee, Kyoung Hwa; Park, Jae Woo; Lee, Nam Ho; Na, Hye Kyung; Surh, Young-Joon; You, Ho Jin; Chung, Myung Hee; Hyun, Jin Won
- Issue Date
- FEBS Letters, Vol.581 No.10, pp.2000-2008
- Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heine oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-I activity. Transcription factor NF-E2 related factor 2 (Nrf2) regulates antioxidant response element (ARE) of phase 2 detoxifying and antioxidant enzymes. Triphlorethol-A increased nuclear translocation, ARE binding, and transcriptional activity of Nrf2. Triphlorethol-A exhibited activation of ERK and U0126, inhibitor of ERK kinase, suppressed triphlorethol-A induced activation of Nrf2, finally decreased HO-1 protein level. Taken together, these data suggest that triphlorethol-A augments cellular antioxidant defense capacity through induction of HO-I via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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