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Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger

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Authors
Surh, Young-Joon; Park, Kwang-kyun; Chun, Kyung-soo; Lee, Jong Min; Lee, Eunyong; Lee, Sang-sup
Issue Date
1999
Citation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.18 No.2, pp.131-139
Keywords
[6]- paradol[6]-gingerolAntiinflammationAntitumor promotionChemopreventionGingerMouse skin carcinogenesisOrnithine decarboxylase activityVanilloids
Abstract
Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including [6]-gingerol and [6]paradol, and has been reported to possess a strong anti-inflammatory activity. These pungent substances have a vanilloid structure found in other chemopreventive phytochemicals, including curcumin. In our study, we found anti-tumor-promoting properties of [6]-gingerol and [6]-paradol. Thus, topical application of [6]-gingerol or [6]-paradol 30 min prior to 12-O- tetradecanoylphorbol-13-acetate (TPA) attenuated the skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene in female ICR mice. These substances also significantly inhibited the tumor-promoter-stimulated inflammation, TNF-α production, and activation of epidermal ornithine decarboxylase in mice. In another study, [6]-gingerol and [6]-paradol suppressed the superoxide production stimulated by TPA in differentiated HL- 60 cells. Taken together, these findings suggest that pungent vanilloids found in ginger possess potential chemopreventive activities.
ISSN
0731-8898
URI
https://hdl.handle.net/10371/172783
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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