S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger
- Surh, Young-Joon; Park, Kwang-kyun; Chun, Kyung-soo; Lee, Jong Min; Lee, Eunyong; Lee, Sang-sup
- Issue Date
- Journal of Environmental Pathology, Toxicology and Oncology, Vol.18 No.2, pp.131-139
- - paradol; -gingerol; Antiinflammation; Antitumor promotion; Chemoprevention; Ginger; Mouse skin carcinogenesis; Ornithine decarboxylase activity; Vanilloids
- Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been widely used as a dietary spice, as well as in traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including -gingerol and paradol, and has been reported to possess a strong anti-inflammatory activity. These pungent substances have a vanilloid structure found in other chemopreventive phytochemicals, including curcumin. In our study, we found anti-tumor-promoting properties of -gingerol and -paradol. Thus, topical application of -gingerol or -paradol 30 min prior to 12-O- tetradecanoylphorbol-13-acetate (TPA) attenuated the skin papillomagenesis initiated by 7,12-dimethylbenz[a]anthracene in female ICR mice. These substances also significantly inhibited the tumor-promoter-stimulated inflammation, TNF-α production, and activation of epidermal ornithine decarboxylase in mice. In another study, -gingerol and -paradol suppressed the superoxide production stimulated by TPA in differentiated HL- 60 cells. Taken together, these findings suggest that pungent vanilloids found in ginger possess potential chemopreventive activities.
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