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Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Kim, Do-Hee; Na, Hye-Kyung; Oh, Tae Young; Shin, Chang-Yell; Surh, Young-Joon
Issue Date
2005
Citation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24 No.4, pp.251-259
Keywords
Artemisia asiaticaeupatilinMCF-10A-ras cellscell proliferationcell cycle arrestcyclin D1AP-1c-Junp21(waf1/Cip1)
Abstract
Artemisia asiatica Nakai has been used frequently in traditional Asian medicine for the treatment of inflammation and cancer. Eupatilin (5,7-dihydroxy-3',4', 6-trimethoxy-flavone) was shown to be a pharmacologically active ingredient of A asiatica. In the present study, we found that expression of cyclin D1, a key protein that regulates G(1)/S progression, was decreased in MCF-10A-ras cells treated with eupatilin. Downregulation of cyclin D1 expression by eupatifin was accompanied by a reduced expression of c-Jun and the DNA binding activity of the transcription factor AP-1. The expression of p21(waf1/Cip1) was also decreased by eupatilin treatment in both protein and the mRNA levels. We concluded that the inhibitory effect of eupatilin on p21(waf1/Cip1) expression is likely to be associated with the downregulation of cyclin D1 expression and AP-1 activation, which play an important role in the cell cycle arrest of ras-transformed breast epithelial cells.
ISSN
0731-8898
URI
https://hdl.handle.net/10371/172784
DOI
https://doi.org/10.1615/JEnvironPatholToxicolOncol.v24.i4.20
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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