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Chemoprotective properties of some pungent ingredients present in red pepper and ginger

Cited 149 time in Web of Science Cited 181 time in Scopus
Authors
Surh, Young-Joon; Lee, Eunyong; Lee, Jong Min
Issue Date
1998-06
Citation
Mutation Research, Vol.402 No.1-2, pp.259-267
Keywords
red peppergingercapsaicingingeroldiarylheptanoidschemoprevention
Abstract
There has been a substantial body of data, supporting that dietary factors have a profound impact on prevention as well as etiology of human cancer. Capsaicin has been tested by many investigators for its effects on experimental carcinogenesis and mutagenesis. Data in the literature indicate that capsaicin has dual effects on carcinogenic and mutagenic processes. At present, there is no solid evidence that hot red and chili peppers or their principal pungent ingredient capsaicin are carcinogenic in humans although results of early investigations with experimental animals exhibit the moderate tumorigenicity of this compound. In contrast, recent studies reveal substantial antigenotoxic and anticarcinogenic effects of capsaicin, suggesting this compound as another important dietary phytochemical with a potential chemopreventive activity. Some pungent constituents present in ginger and other zingiberaceous plants have potent antioxidant and anti-inflammatory effects, and some of them exhibit anti-tumor promotional activity in experimental carcinogenesis. (C) 1998 Elsevier Science B.V. All rights reserved.
ISSN
0027-5107
URI
https://hdl.handle.net/10371/172860
DOI
https://doi.org/10.1016/S0027-5107(97)00305-9
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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