S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Antioxidative and antitumor promoting effects of -paradol and its homologs
- Chung, Won-Yoon; Jung, Yeon-Joo; Surh, Young-Joon; Lee, Sang-Sup; Park, Kwang-Kyun
- Issue Date
- Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol.496 No.1-2, pp.199-206
- -paradol; -dehydroparadol; vanilloids; mouse skin carcinogenesis; ornithine decarboxylase; antitumor promoting activity
- Recently, considerable attention is focused on anti-carcinogenic phytochemicals, particularly those derived from medicinal or edible plants. -Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. The compound has been reported to attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells. In this study, we performed several biochemical studies to evaluate and compare the cancer chemopreventive potential of -paradol and its synthetic derivatives. -Paradol and its synthetic nonpungent analog, -dehydroparadol significantly decreased the incidence and the multiplicity of skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-0-tetradecanoylphorbol-13-acetate (TPA). Topical application of -paradol and its derivatives inhibited TPA-induced ear edema and H2O2 production and myeloperoxidase activity in the dorsal skin of mice. Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H2O2- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. These results indicate that -paradol and its derivatives possess the cancer chemopreventive potential. (C) 2001 Elsevier Science B.V. All rights reserved.
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