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Induction of cyclooxygenase-2 in ras-transformed human mammary epithelial cells undergoing apoptosis

Cited 16 time in Web of Science Cited 16 time in Scopus
Authors
Na, Hye-Kyung; Surh, Young-Joon
Issue Date
2002
Citation
Annals of the New York Academy of Sciences, Vol.973, pp.153-160
Keywords
apoptosiscelecoxibcyclooxygenase-2 (COX-2)ET-18-O-CH3human breast epithelial cellsras-transformed cells
Abstract
COX-2 expression has been reported to be elevated in several forms of human cancer. The presence of oncogenic ras has been associated with constitutive induction of COX-2, which confers resistance to apoptosis. Contrary to the above notion, we have found that H-ras-transformed human breast epithelial (MCF10A-ras) cells treated with the anticancer drug ET-18-0-CH3 exhibit an increased expression of COX-2, while they still undergo apoptosis. To determine whether the induction of COX-2 by ET-18-0-CH3 could contribute to apoptosis in MCF10A-ras cells, the selective COX-2 inhibitor celecoxib (SC-58635) was used. Celecoxib treatment attenuated ET-18-0-CH3-induced cell death. Taken together, the above findings suggest that COX-2 up-regulation does not necessarily confer the resistance to apoptosis in ras-transformed cells, but rather may sensitize these cells to apoptotic death.
ISSN
0077-8923
URI
https://hdl.handle.net/10371/172880
DOI
https://doi.org/10.1111/j.1749-6632.2002.tb04626.x
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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