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Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol
Cited 130 time in
Web of Science
Cited 163 time in Scopus
- Authors
- Issue Date
- 2001-02
- Publisher
- American Association for Cancer Research
- Citation
- Cancer Research, Vol.61 No.3, pp.850-853
- Abstract
- Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms.
- ISSN
- 0008-5472
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