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Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol

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Authors
Bode, Ann M.; Ma, Wei-Ya; Surh, Young-Joon; Dong, Zigang
Issue Date
2001-02
Citation
Cancer Research, Vol.61 No.3, pp.850-853
Abstract
Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms.
ISSN
0008-5472
URI
https://hdl.handle.net/10371/172895
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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