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Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol
Cited 171 time in
Web of Science
Cited 198 time in Scopus
- Authors
- Issue Date
- 1998-12
- Publisher
- Elsevier BV
- Citation
- Cancer Letters, Vol.134 No.2, pp.163-168
- Abstract
- [6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
- ISSN
- 0304-3835
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