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Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol

Cited 141 time in Web of Science Cited 171 time in Scopus
Authors
Lee, Eunyong; Surh, Young-Joon
Issue Date
1998-12
Citation
Cancer Letters, Vol.134 No.2, pp.163-168
Keywords
[6]-gingerol[6]-paradolapoptosisHL-60 cellsginger
Abstract
[6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://hdl.handle.net/10371/172914
DOI
https://doi.org/10.1016/S0304-3835(98)00253-5
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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