S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Induction of apoptosis in HL-60 cells by pungent vanilloids, -gingerol and -paradol
- Lee, Eunyong; Surh, Young-Joon
- Issue Date
- Cancer Letters, Vol.134 No.2, pp.163-168
- -Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. -Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, -gingerol and -paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that -gingerol and -paradol possess potential cytotoxic/cytostatic activities. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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