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Mutation of ras oncogene in gastric adenocarcinoma: Association with histological phenotype
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, TY | - |
dc.contributor.author | Bang, YJ | - |
dc.contributor.author | Kim, WS | - |
dc.contributor.author | Kang, SH | - |
dc.contributor.author | Lee, KU | - |
dc.contributor.author | Choe, KJ | - |
dc.contributor.author | Kim, NK | - |
dc.date.accessioned | 2021-01-31T11:00:56Z | - |
dc.date.available | 2021-01-31T11:00:56Z | - |
dc.date.created | 2020-12-22 | - |
dc.date.issued | 1997-03 | - |
dc.identifier.citation | Anticancer Research, Vol.17 No.2B, pp.1335-1339 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.other | 119569 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172965 | - |
dc.description.abstract | In order to explore the role of ras oncogene in gastric carcinomas from Korean patients, we examined the frequency of point mutations all three ras oncogenes (Ki-, Ha-, and N-ras). A total of 57 DNA samples were prepared from 3 gastric carcinoma cell lines, 10 malignant ascites, and 44 frozen gastric tremor tissues. Exons I and 2 of each ras oncogene were amplified by polymerase chain reaction (PCR), and analyzed by single strand conformation polymorphism (SSCP) and direct sequencing. Mutated ms genes were detected in 6 out of 57 samples (10%). One cell line and 2 tumors showed a mutation at exon 1 of Ki-ras. N-ras mutations were also detected at exon I of 3 tumors. Histologically, all the ras mutation cases exhibited a diffuse phenotype. In summary, we performed a comprehensive analysis to investigate the mutation of all three ms oncogenes in gastric carcinoma. The results demonstrate infrequent mutations of Ki-and N-ras which may favor the development of diffuse type gastric carcinomas, implicating a different genetic pathway in diffuse and intestinal type gastric carcinomas. | - |
dc.language | 영어 | - |
dc.publisher | International Institute of Anticancer Research | - |
dc.title | Mutation of ras oncogene in gastric adenocarcinoma: Association with histological phenotype | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.citation.journaltitle | Anticancer Research | - |
dc.identifier.wosid | A1997WU02400019 | - |
dc.identifier.scopusid | 2-s2.0-0030894070 | - |
dc.citation.endpage | 1339 | - |
dc.citation.number | 2B | - |
dc.citation.startpage | 1335 | - |
dc.citation.volume | 17 | - |
dc.identifier.sci | A1997WU02400019 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, TY | - |
dc.contributor.affiliatedAuthor | Bang, YJ | - |
dc.contributor.affiliatedAuthor | Lee, KU | - |
dc.contributor.affiliatedAuthor | Choe, KJ | - |
dc.contributor.affiliatedAuthor | Kim, NK | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | POLYMERASE CHAIN-REACTION | - |
dc.subject.keywordPlus | POINT MUTATIONS | - |
dc.subject.keywordPlus | CANCERS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CODON-12 | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | gastric carcinoma | - |
dc.subject.keywordAuthor | ras oncogene | - |
dc.subject.keywordAuthor | point mutation | - |
dc.subject.keywordAuthor | polymerase chain reaction | - |
dc.subject.keywordAuthor | sequencing | - |
dc.subject.keywordAuthor | differentiation | - |
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