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Phase I study of weekly docetaxel and cisplatin concurrent with thoracic radiotherapy in stage III non-small-cell lung cancer

Cited 34 time in Web of Science Cited 40 time in Scopus
Authors
Wu, Hong Gyun; Bang, Yung-Jue; Choi, Eun Kyung; Ahn, Yong Chan; Kim, Young Whan; Lim, Tae-Hwan; Suh, Cheolwon; Park, Keunchil; Park, Charn Il
Issue Date
2002-01
Citation
International Journal of Radiation Oncology Biology Physics, Vol.52 No.1, pp.75-80
Keywords
non-small-cell lung cancercombined chemotherapy and radiotherapydocetaxel
Abstract
Purpose: This is the first report of a Phase I study on concomitant weekly cisplatin and docetaxel chemotherapy with thoracic radiation for Stage III non-small-cell lung cancer (NSCLC). The study objectives were to determine the maximum tolerable dose (MTD) and dose-limiting toxicity (DLT) of docetaxel used in this regimen, and to evaluate the feasibility of weekly concurrent chemoradiotherapy. Methods and Materials: Patients with histologically proven and unresectable Stage III NSCLC were the subjects of this study. Cisplatin was administered at a fixed dose of 20 mg/m(2), while the dose of docetaxel was increased from 0 to 30 mg/m(2) in increments of 10 mg/m(2). Chemotherapy was given on the first day of each week for 6 weeks. The primary tumor and regional lymph nodes were irradiated to 54 Gy, followed by an additional 9 Gy boost to the primary tumor, making the total dose 63 Gy at 1.8 Gy/fraction. Results: Sixteen men and 2 women with advanced NSCLC without prior treatment were enrolled. The median age of the group was 58 years (range 49-67). Three patients had Stage IIIa disease and 15 patients had IIIb disease. Dose-limiting Grade 3 esophagitis was encountered at a docetaxel dose level of 30 mg/m2 in 2 of 3 patients. No dose-limiting, nonhematologic toxicity occurred in the other patients and no dose-limiting hematologic toxicity occurred in any patient. Conclusion: The treatment schedule for NSCLC was feasible, with the DLT being esophagitis. We determined the recommended dose of docetaxel to be 20 mg/m(2) for a Phase II study when combined with weekly cisplatin and concomitant thoracic RT. (C) 2002 Elsevier Science Inc.
ISSN
0360-3016
URI
https://hdl.handle.net/10371/173129
DOI
https://doi.org/10.1016/S0360-3016(01)01739-4
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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