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Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Jin Won | - |
dc.contributor.author | Cho, Sung-Yup | - |
dc.contributor.author | Chae, Jeesoo | - |
dc.contributor.author | Kim, Ji-Won | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Oh, Do-Youn | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.date.accessioned | 2021-01-31T12:00:30Z | - |
dc.date.available | 2021-01-31T12:00:30Z | - |
dc.date.created | 2020-11-02 | - |
dc.date.created | 2020-11-02 | - |
dc.date.created | 2020-11-02 | - |
dc.date.created | 2020-11-02 | - |
dc.date.created | 2020-11-02 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | Cancer Research and Treatment, Vol.52 No.4, pp.1178-1187 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.other | 114630 | - |
dc.identifier.uri | https://hdl.handle.net/10371/173203 | - |
dc.description.abstract | Purpose Microsatellite instability (MSI) status may affect the efficacy of adjuvant chemotherapy in gastric cancer. In this study, the clinical characteristics of MSI-high (MSI-H) gastric cancer and the predictive value of MSI-H for adjuvant chemotherapy in large cohorts of gastric cancer patients were evaluated. Materials and Methods This study consisted of two cohorts. Cohort 1 included gastric cancer patients who received curative resection with pathologic stage IB-IIIC. Cohort 2 included patients with MSI-H gastric cancer who received curative resection with pathologic stage II/III. MSI was examined using two mononucleotide markers and three dinucleotide markers. Results Of 359 patients (cohort 1), 41 patients (11.4%) had MSI-H. MSI-H tumors were more frequently identified in older patients (p < 0.001), other histology than poorly cohesive, signet ring cell type (p=0.005), intestinal type (p=0.028), lower third tumor location (p=0.005), and absent perineural invasion (p=0.027). MSI-H status has a tendency of better disease-free survival (DFS) and overall survival (OS) in multivariable analyses (hazard ratio [HR], 0.4; p=0.059 and HR, 0.4; p=0.063, respectively). In the analysis of 162 MSI-H patients (cohort 2), adjuvant chemotherapy showed a significant benefit with respect to longer DFS and OS (p=0.047 and p=0.043, respectively). In multivariable analysis, adjuvant chemotherapy improved DFS (HR, 0.4; p=0.040). Conclusion MSI-H gastric cancer had distinct clinicopathologic findings. Even in MSI-H gastric cancer of retrospective cohort, adjuvant chemotherapy could show a survival benefit, which was in contrast to previous prospective studies and should be investigated in a further prospective trial. | - |
dc.language | 영어 | - |
dc.publisher | 대한암학회 | - |
dc.title | Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.4143/crt.2020.313 | - |
dc.citation.journaltitle | Cancer Research and Treatment | - |
dc.identifier.wosid | 000579859000018 | - |
dc.identifier.scopusid | 2-s2.0-85093889819 | - |
dc.citation.endpage | 1187 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 1178 | - |
dc.citation.volume | 52 | - |
dc.identifier.sci | 000579859000018 | - |
dc.identifier.kciid | ART002636271 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Sung-Yup | - |
dc.contributor.affiliatedAuthor | Kim, Ji-Won | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.contributor.affiliatedAuthor | Oh, Do-Youn | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | III COLON-CANCER | - |
dc.subject.keywordPlus | MISMATCH-REPAIR | - |
dc.subject.keywordPlus | STAGE-II | - |
dc.subject.keywordPlus | OXALIPLATIN | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordAuthor | Microsatellite instability | - |
dc.subject.keywordAuthor | Adjuvant chemotherapy | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
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