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Neoadjuvant chemotherapy followed by radiotherapy in epidermoid carcinoma of anus

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Authors
Chie, Eui Kyu; Wu, Hong Gyun; Heo, Dae Seog; Bang, Young-Jue; Kim, Noe Kyeong; Ha, Sung W.
Issue Date
2004-05
Citation
Tumori, Vol.90 No.3, pp.299-302
Keywords
anal cancerneoadjuvant chemotherapyradiotherapy
Abstract
Aim and background: The purpose of this study was to analyze the efficacy of neoadjuvant fluorouracil-cisplatin chemotherapy combined with radiotherapy for anal cancer. Methods: Fourteen patients with epidermoid carcinoma of the anal canal were analyzed. Treatment consisted of three cycles of 5-fluorouracil (1000 mg/m(2) bolus on days 1-5) and cisplatin (60 mg/m(2) bolus on day 1) followed by 50.4 Gy to the pelvis and perineum over 5.5 weeks. Both inguinal lymphatics were irradiated with an identical dose schedule. The median follow-up was 78 months. Results: Five-year overall survival rate and sphincter preservation rate was 85.1% and 85.7%, respectively. Response to chemoradiotherapy was the only significant factor with univariate analysis (P = 0.031). There were no complications of RTOG grade 3 or higher. Conclusions: Neoadjuvant chemotherapy with a cisplatin-based regimen rather than concurrent regimen plus radiotherapy may decrease complications without compromising survival or sphincter preservation.
ISSN
0300-8916
URI
https://hdl.handle.net/10371/173269
DOI
https://doi.org/10.1177/030089160409000307
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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