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Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses

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Authors
Park, Pojeong; Kang, Heather; Georgiou, John; Zhuo, Min; Kaang, Bong-Kiun; Collingridge, Graham L
Issue Date
2021-02-01
Publisher
BMC
Citation
Molecular Brain. 2021 Feb 01;14(1):26
Keywords
Synaptic tag and capture, Synapse specifcitySynaptic efcacySynaptic potentiationHeterosynaptic plasticityMetaplasticityLearningMemory
Abstract
The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a crucial component of this form of heterosynaptic metaplasticity. Here we have investigated two predictions that arise on the basis of CP-AMPARs serving as a trigger of STC. Firstly, we compared the effects of the order in which we delivered a strong theta burst stimulation (TBS) protocol (75 pulses) and a weak TBS protocol (15 pulses) to two independent inputs. We only observed significant heterosynaptic metaplasticity when the strong TBS preceded the weak TBS. Second, we found that pausing stimulation following either the sTBS or the wTBS for ~20 min largely eliminates the heterosynaptic metaplasticity. These observations are consistent with a process that is triggered by the synaptic insertion of CP-AMPARs and provide a framework for establishing the underlying molecular mechanisms.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/174195
DOI
doi.org/10.1186/s13041-021-00737-2
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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