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Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

Cited 13 time in Web of Science Cited 13 time in Scopus
Issue Date
2021-04-13
Publisher
Springer Open
Citation
Nano Convergence. 2021 Apr 13;8(1):12
Keywords
MicrofuidicsTumor organoidsMicrovasculatureOrgan-on-a-chip
Abstract
Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine.
ISSN
2196-5404
Language
English
URI
https://hdl.handle.net/10371/174675
DOI
https://doi.org/10.1186/s40580-021-00261-y
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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