Browse

Simultaneous determination of multi-class veterinary drugs in fishery products with liquid chromatography–tandem mass spectrometry

Cited 1 time in Web of Science Cited 1 time in Scopus
Issue Date
2021-05-10
Publisher
Springer Open
Citation
Applied Biological Chemistry. 2021 May 10;64(1):40
Keywords
Analytical methodsFishery productLC–MS/MSMulti-class analysisVeterinary drugs
Abstract
The objective of this study was to optimize the analytical method for multi-class veterinary drug residues of 64 compounds in fishery products. Several compounds from veterinary drugs are banned or unauthorized in fishery products according to the Korean Food Code. Samples were extracted using acetonitrile/water (4:1, v/v) and the clean-up step was carried out by adding octadecylsilane and acetonitrile-saturated hexane. The target compounds were confirmed and quantified using liquid chromatography–tandem mass spectrometry (LC–MS/MS). The proposed method was validated according to the CODEX guidelines (CAC/GL-71), and most target compounds were found to be in acceptable quantities under the requirements of the validation guidelines. The recovery of analytes was typically in the 60–120% range, and precision, expressed as the coefficient of variation was less than 31% at all levels of concentration. The limit of quantification ranged from 0.03 to 3 μg kg−1 in the fishery products. Moreover, the application of the proposed method to 96 real samples demonstrated that no drug residues exceeded the Korean maximum residue limits (MRLs). This evaluation method provides reliable identification and quantification of multi-class veterinary drugs in fishery products and can be an efficient means to inspect drugs currently banned or not approved for aquaculture in Korea.
ISSN
2468-0842
Language
English
URI
https://hdl.handle.net/10371/174759
DOI
https://doi.org/10.1186/s13765-021-00611-8
Files in This Item:
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse