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Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bian, Yiying | - |
dc.contributor.author | Chung, Han-Young | - |
dc.contributor.author | Bae, Ok-Nam | - |
dc.contributor.author | Lim, Kyung-Min | - |
dc.contributor.author | Chung, Jin-Ho | - |
dc.contributor.author | Pi, Jingbo | - |
dc.date.accessioned | 2021-08-27T05:41:32Z | - |
dc.date.available | 2021-08-27T14:42:53Z | - |
dc.date.issued | 2021-08-04 | - |
dc.identifier.citation | Particle and Fibre Toxicology. 2021 Aug 04;18(1):28 | ko_KR |
dc.identifier.issn | 1743-8977 | - |
dc.identifier.uri | https://hdl.handle.net/10371/174838 | - |
dc.description.abstract | Background
Expanding biomedical application of anatase titanium dioxide (TiO2) nanoparticles (NPs) is raising the public concern on its potential health hazards. Here, we demonstrated that TiO2 NPs can increase phosphatidylserine (PS) exposure and procoagulant activity of red blood cells (RBCs), which may contribute to thrombosis. Results We conducted in vitro studies using RBCs freshly isolated from healthy male volunteers. TiO2 NPs exposure (≦ 25 μg/mL) induced PS exposure and microvesicles (MV) generation accompanied by morphological changes of RBCs. While ROS generation was not observed following the exposure to TiO2 NPs, intracellular calcium increased and caspase-3 was activated, which up-regulated scramblase activity, leading to PS exposure. RBCs exposed to TiO2 NPs could increase procoagulant activity as measured by accelerated thrombin generation, and enhancement of RBC-endothelial cells adhesion and RBC-RBC aggregation. Confirming the procoagulant activation of RBC in vitro, exposure to TiO2 NPs (2 mg/kg intravenously injection) in rats increased thrombus formation in the venous thrombosis model. Conclusion Collectively, these results suggest that anatase TiO2 NPs may harbor prothrombotic risks by promoting the procoagulant activity of RBCs, which needs attention for its biomedical application. | ko_KR |
dc.description.sponsorship | This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MSIP)
(2015R1A2A2A01011705), National Natural Science Foundation of China (No.82020108027 and No.82003500) as well as the Talent Introduction Program of Postdoctoral International Exchange Program (No. YJ20190263). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Titanium dioxide nanoparticles (TiO2 NPs) | - |
dc.subject | Phosphatidylserine (PS) exposure | - |
dc.subject | Procoagulant activity | - |
dc.subject | Thrombosis | - |
dc.subject | Red blood cells (RBCs) | - |
dc.title | Titanium dioxide nanoparticles enhance thrombosis through triggering the phosphatidylserine exposure and procoagulant activation of red blood cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정한영 | - |
dc.contributor.AlternativeAuthor | 배옥남 | - |
dc.contributor.AlternativeAuthor | 임경민 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1186/s12989-021-00422-1 | - |
dc.citation.journaltitle | Particle and Fibre Toxicology | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-08-08T03:30:12Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 28 | ko_KR |
dc.citation.volume | 18 | ko_KR |
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