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The antioxidant methyl gallate inhibits fungal growth and deoxynivalenol production in Fusarium graminearum

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Issue Date
2021-09-22
Publisher
BMC
Citation
Food Production, Processing and Nutrition. 2021 Sep 22;3(1):27
Keywords
Fusarium graminearumAntioxidant methyl gallateDeoxynivalenol productionMechanism of action
Abstract
Production of the Fusarium toxin deoxynivalenol (DON) is associated with oxidative stress and has been indicated to be part of an adaptive response to oxidative stress in the important wheat fungus Fusarium graminearum. In this study, we found that the antioxidant methyl gallate (MG) displays inhibitory effects against mycelial growth, conidial formation and germination, and DON biosynthesis in F. graminearum in a dose-dependent manner. Treatment with 0.05% (w/v) MG resulted in an abnormal swollen conidial morphology. The expression of the TRI genes involved in DON biosynthesis was significantly reduced, and the induction of Tri1-GFP green fluorescence signals in the spherical and crescent-shaped toxisomes was abolished in the MG-treated mycelium. RNA-Seq analysis of MG-treated F. graminearum showed that 0.5% (w/v) MG inhibited DON production by possibly altering membrane functions and oxidoreductase activities. Coupled with the observations that MG treatment decreases catalase, POD and SOD activity in F. graminearum. The results of this study indicated that MG displays antifungal activity against DON production by modulating its oxidative response. Taken together, the current study revealed the potential of MG in inhibiting mycotoxins in F. graminearum.


Graphical abstract
ISSN
2661-8974
Language
English
URI
https://hdl.handle.net/10371/176920
DOI
https://doi.org/10.1186/s43014-021-00070-0
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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