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How cancer cells remodel lipid metabolism: strategies targeting transcription factors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Do-Won | - |
dc.contributor.author | Lee, Seulbee | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.date.accessioned | 2022-03-02T01:42:30Z | - |
dc.date.available | 2022-03-02T10:45:42Z | - |
dc.date.issued | 2021-11-14 | - |
dc.identifier.citation | Lipids in Health and Disease. 2021 Nov 14;20(1):163 | ko_KR |
dc.identifier.issn | 1476-511X | - |
dc.identifier.uri | https://hdl.handle.net/10371/176995 | - |
dc.description.abstract | Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy. | ko_KR |
dc.description.sponsorship | This work was supported by National Research Foundation of Korea (No.2019R1A2C2083886, 2018R1A5A2025964). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Lipid metabolism | - |
dc.subject | Transcription factor | - |
dc.subject | Cancer | - |
dc.title | How cancer cells remodel lipid metabolism: strategies targeting transcription factors | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정도원 | - |
dc.contributor.AlternativeAuthor | 이슬비 | - |
dc.contributor.AlternativeAuthor | 전양숙 | - |
dc.identifier.doi | https://doi.org/10.1186/s12944-021-01593-8 | - |
dc.citation.journaltitle | Lipids in Health and Disease | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2021-11-21T04:21:22Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 163 | ko_KR |
dc.citation.volume | 20 | ko_KR |
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