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Neoadjuvant Chemotherapy Followed by Limited Surgery in a Mouse Model of Head and Neck Cancer

Cited 4 time in Web of Science Cited 3 time in Scopus
Authors

Lee, Jae Jin; Hah, Jeong-Hun; Im, Seock-Ah; Kim, Si-Young; Sung, Myung-Whun; Kim, Kwang Hyun; Heo, Dae Soeg

Issue Date
2009-01
Publisher
International Institute of Anticancer Research
Citation
Anticancer Research, Vol.29 No.1, pp.255-259
Abstract
Background: This study evaluated the effect of limited surgery following neoadjuvant chemotherapy compared to radical surgery in SCC VII (squamous cell cancer) tumor-bearing syngeneic C3H/HeJ mice. Materials and Methods: Mice showing a tumor response to cisplatin and 5-fluorouracil therapy were divided into three groups: radical surgery, with a 5 nun margin from the original tumor, group (A); limited surgery of 5 mm margin from the residual tumor, group (B); and very limited surgery with no margin from the residual tumor, group (C). The number of mice was 13 (group A), 12 (group B) and 12 (group C). Results: No recurrence developed except in one mouse in group C. Three mice died in group A, one in group B and one in group C from perioperative complications. By intent-to-treat analysis, the survival was not significantly different among the three groups (p=0.64), or between group A and B (p=0.33). Conclusion: The outcome of limited surgery was comparable to radical surgery after neoadjuvant chemotherapy in the mouse model of head and neck cancer.
ISSN
0250-7005
URI
https://hdl.handle.net/10371/177150
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  • College of Medicine
  • Department of Medicine
Research Area Clinical Medicine

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