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Early prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel H-1-magnetic resonance spectroscopy and F-18-fluorodeoxyglucose positron emission tomography
DC Field | Value | Language |
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dc.contributor.author | Cho, Nariya | - |
dc.contributor.author | Im, Seock-Ah | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Park, In-Ae | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Lee, Kyung-Hun | - |
dc.contributor.author | Kim, Tae-Yong | - |
dc.contributor.author | Lee, Hyunjong | - |
dc.contributor.author | Chun, In Kook | - |
dc.contributor.author | Yoon, Hai-Jeon | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.date.accessioned | 2022-03-22T09:23:15Z | - |
dc.date.available | 2022-03-22T09:23:15Z | - |
dc.date.created | 2018-09-03 | - |
dc.date.created | 2018-09-03 | - |
dc.date.created | 2018-09-03 | - |
dc.date.created | 2018-09-03 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | European Radiology, Vol.26 No.7, pp.2279-2290 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.other | 49865 | - |
dc.identifier.uri | https://hdl.handle.net/10371/177286 | - |
dc.description.abstract | To prospectively compare performances of single-voxel proton magnetic resonance spectroscopy (H-1-MRS) and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pathologic response to neoadjuvant chemotherapy (NAC) in breast cancer patients. Thirty-five breast cancer patients who received NAC and subsequent surgery were prospectively enrolled. MRS and FDG-PET were performed before and after the 1st NAC cycle. Percentage changes of total choline-containing compounds (tCho) via MRS, and maximum and peak standardized uptake values (SUVmax, SUVpeak) and total lesion glycolysis (TLG) via FDG-PET were measured, and their performances in predicting pathologic complete response (pCR) were compared. Of the 35 patients, 6 showed pCR and 29 showed non-pCR. Mean % reductions of tCho, SUVmax, SUVpeak, and TLG of the pCR group were larger than those of the non-pCR group (-80.3 +/- 13.9 % vs. -32.1 +/- 49.4 %, P = 0.025; -54.7 +/- 22.1 % vs. -26.3 +/- 33.7 %, P = 0.058; -60.7 +/- 18.3 % vs. -32.3 +/- 23.3 %, P = 0.009; -89.5 +/- 8.5 % vs. -52.6 +/- 36.2 %, P = 0.020). Diagnostic accuracy (area under ROC curve; Az, 0.911) of the % reduction of tCho was comparable to those of %SUVmax (0.822), SUVpeak (0.862), and TLG (0.879) in distinguishing pCR from non-pCR (all P > 0.05). MRS showed comparable performance to FDG-PET in early prediction of pCR in breast cancer patients. aEuro cent MRS can predict response to NAC in breast cancer post-1 (st) cycle. aEuro cent Changes in tCho and SUV after NAC reflect tumour cellularity changes. aEuro cent MRS can be an alternative to FDG-PET in predicting response to NAC. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Early prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel H-1-magnetic resonance spectroscopy and F-18-fluorodeoxyglucose positron emission tomography | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1007/s00330-015-4014-7 | - |
dc.citation.journaltitle | European Radiology | - |
dc.identifier.wosid | 000377996200034 | - |
dc.identifier.scopusid | 2-s2.0-84941670486 | - |
dc.citation.endpage | 2290 | - |
dc.citation.number | 7 | - |
dc.citation.startpage | 2279 | - |
dc.citation.volume | 26 | - |
dc.identifier.sci | 000377996200034 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Nariya | - |
dc.contributor.affiliatedAuthor | Im, Seock-Ah | - |
dc.contributor.affiliatedAuthor | Kang, Keon Wook | - |
dc.contributor.affiliatedAuthor | Park, In-Ae | - |
dc.contributor.affiliatedAuthor | Moon, Woo Kyung | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | H-1 MR SPECTROSCOPY | - |
dc.subject.keywordPlus | PATHOLOGICAL RESPONSE | - |
dc.subject.keywordPlus | MALIGNANT-TRANSFORMATION | - |
dc.subject.keywordPlus | SYSTEMIC THERAPY | - |
dc.subject.keywordPlus | FDG-PET | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECOMMENDATIONS | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | Breast neoplasm | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Magnetic resonance spectroscopy | - |
dc.subject.keywordAuthor | Positron emission tomography | - |
dc.subject.keywordAuthor | Neoadjuvant chemotherapy | - |
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