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Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Nam, Chang Hyun | - |
dc.contributor.author | Koh, Jaemoon | - |
dc.contributor.author | Ock, Chan-Young | - |
dc.contributor.author | Kim, Miso | - |
dc.contributor.author | Keam, Bhumsuk | - |
dc.contributor.author | Kim, Tae Min | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.date.accessioned | 2022-04-20T10:27:59Z | - |
dc.date.available | 2022-04-20T10:27:59Z | - |
dc.date.created | 2021-07-21 | - |
dc.date.created | 2021-07-21 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.citation | The Korean Journal of Internal Medicine, Vol.36 No.4, pp.975-984 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.other | 137975 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179097 | - |
dc.description.abstract | Background Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer. Methods: This study included patients with non-small cell lung cancer who underwent surgery or biopsy and evaluation of PD-L1 expression in tumor cells via immunohistochemistry more than twice. We set the threshold of PD-L1 positivity to 10% and categorized patients into four groups according to changes in PD-L1. expression. Clinicopathologic information was collected from medical records. Statistical analyses, including Fisher's exact test and log-rank test, were performed. Results: Of 109 patients, 38 (34.9%) and 45 (41.3%) had PD-L1 positivity in archival and recent samples, respectively. PD-L1 status was maintained in 78 (71.6%) patients, but changed in 31 (28.4%), with 19 (17.4%) from negative to positive. There were no significant differences in characteristics between patients who maintained PD-L1 negativity and whose PD-L1 status changed from negative to positive. Patients harboring PD-L1 positivity in either archival or recent samples achieved better responses (p = 0.129) and showed longer overall survival than those who maintained PD-L1 negativity when they received immune checkpoint inhibitors after platinum failure (median overall survival 14.4 months vs. 4.93 months; hazard ratio, 0.43; 95% confidence interval, 0.20 to 0.93). Conclusions: PD-L1 status changed in about one-fourth of patients. PD-L1 positivity in either archival or recent samples was predictive of better responses to immune checkpoint inhibitors. Therefore, archival samples could be used for assessment of PD-L1 status. The need for new biopsies should be decided individually. | - |
dc.language | 영어 | - |
dc.publisher | 대한내과학회 | - |
dc.title | Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
dc.contributor.AlternativeAuthor | 하대석 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.identifier.doi | 10.3904/kjim.2020.178 | - |
dc.citation.journaltitle | The Korean Journal of Internal Medicine | - |
dc.identifier.wosid | 000669004600027 | - |
dc.identifier.scopusid | 2-s2.0-85111446282 | - |
dc.citation.endpage | 984 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 975 | - |
dc.citation.volume | 36 | - |
dc.identifier.sci | 000669004600027 | - |
dc.identifier.kciid | ART002728797 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jeon, Yoon Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Chung, Doo Hyun | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | SQUAMOUS-CELL | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordPlus | IMMUNOHISTOCHEMISTRY | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | ASSAYS | - |
dc.subject.keywordAuthor | B7-H1 antigen | - |
dc.subject.keywordAuthor | Immunotherapy | - |
dc.subject.keywordAuthor | Non-small cell lung cancer | - |
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