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Role of Inflammation in Classification of Diabetic Macular Edema by Optical Coherence Tomography

Cited 42 time in Web of Science Cited 48 time in Scopus
Authors

Chung, Yoo-Ri; Kim, Young Ho; Ha, Seong Jung; Byeon, Hye-Eun; Cho, Chung-Hyun; Kim, Jeong Hun; Lee, Kihwang

Issue Date
2019-12
Publisher
Hindawi Publishing Corporation
Citation
Journal of Diabetes Research, Vol.2019, p. 8164250
Abstract
Diabetic macular edema (DME) is the abnormal accumulation of fluid in the subretinal or intraretinal spaces in the macula in patients with diabetic retinopathy and leads to severely impaired central vision. Technical developments in retinal imaging systems have led to many advances in the study of DME. In particular, optical coherence tomography (OCT) can provide longitudinal and microstructural analysis of the macula. A comprehensive review was provided regarding the role of inflammation using OCT-based classification of DME and current and ongoing therapeutic approaches. In this review, we first describe the pathogenesis of DME, then discuss the classification of DME based on OCT findings and the association of different types of DME with inflammation, and finally describe current and ongoing therapeutic approaches using OCT-based classification of DME. Inflammation has an important role in the pathogenesis of DME, but its role appears to differ among the DME phenotypes, as determined by OCT. It is important to determine how the different DME subtypes respond to intravitreal injections of steroids, antivascular endothelial growth factor agents, and other drugs to improve prognosis and responsiveness to treatment.
ISSN
2314-6745
URI
https://hdl.handle.net/10371/179427
DOI
https://doi.org/10.1155/2019/8164250
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