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Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes
DC Field | Value | Language |
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dc.contributor.author | Chung, Yeon-Ho | - |
dc.contributor.author | Kim, Hee Young | - |
dc.contributor.author | Yoon, Bo Ruem | - |
dc.contributor.author | Kang, Yeon Jun | - |
dc.contributor.author | Lee, Won-Woo | - |
dc.date.accessioned | 2022-05-04T01:48:55Z | - |
dc.date.available | 2022-05-04T01:48:55Z | - |
dc.date.created | 2020-04-14 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.citation | Journal of Molecular Medicine, Vol.97 No.3, pp.369-383 | - |
dc.identifier.issn | 0946-2716 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179429 | - |
dc.description.abstract | Monosodium urate (MSU) crystals are an endogenous sterile particulate that has been identified as a potent damage-associated molecular pattern (DAMP). In humans, the induction of IL-1 production through MSU-induced NLRP3 inflammasome activation in monocytes/macrophages is responsible for pathogenesis of gouty arthritis. It was recently reported that in a murine model of this disease, resveratrol decreases MSU-induced recurrent attacks of gouty arthritis. Despite its demonstrated anti-inflammatory effects, the mechanisms underlying resveratrol-mediated repression of IL-1 production in MSU-activated monocytes remain poorly understood. Here, we show that resveratrol suppresses secretion of active IL-1 by human primary monocytes stimulated with MSU crystals through suppression of Syk activation. Metabolic labeling and pull-down assays to investigate de novo protein synthesis clearly demonstrated that intracellular pro-IL-1 synthesis is rapidly repressed in monocytes after resveratrol treatment due to decreased phosphorylation of Syk and p38. Resveratrol also inhibited NLRP3 inflammasome activation in MSU-stimulated monocytes by suppressing oligomerization of ASC. Furthermore, resveratrol exerted a beneficial effect by reducing IL-1 production and inhibiting neutrophil recruitment in a mouse model of MSU-mediated peritonitis. Our findings suggest that resveratrol exerts anti-inflammatory effects via post-translational regulation of IL-1 production and, thus, may prove beneficial for the treatment of MSU crystal-mediated sterile inflammation.Key messageResveratrol has negative effects on pro-IL-1 synthesis through Syk and p38.Resveratrol inhibits oligomerization of ASC.Resveratrol is beneficial in a mouse model of MSU-induced peritonitis. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00109-018-01736-y | - |
dc.citation.journaltitle | Journal of Molecular Medicine | - |
dc.identifier.wosid | 000459442800007 | - |
dc.identifier.scopusid | 2-s2.0-85059931362 | - |
dc.citation.endpage | 383 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 369 | - |
dc.citation.volume | 97 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Lee, Won-Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
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