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Targeting the Epithelium-Derived Innate Cytokines: From Bench to Bedside
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ham, Jongho | - |
dc.contributor.author | Shin, Jae Woo | - |
dc.contributor.author | Ko, Byeong Cheol | - |
dc.contributor.author | Kim, Hye Young | - |
dc.date.accessioned | 2022-05-04T01:49:00Z | - |
dc.date.available | 2022-05-04T01:49:00Z | - |
dc.date.created | 2022-03-29 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.citation | Immune Network, Vol.22 No.1, p. e11 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179433 | - |
dc.description.abstract | When epithelial cells are exposed to potentially threatening external stimuli such as allergens, bacteria, viruses, and helminths, they instantly produce "alarmin" cytokines, namely, IL-33, IL-25, and TSLP. These alarmins alert the immune system about these threats, thereby mobilizing host immune defense mechanisms. Specifically, the alarmins strongly stimulate type-2 immune cells, including eosinophils, mast cells, dendritic cells, type-2 helper T cells, and type-2 innate lymphoid cells. Given that the alarm-raising role of IL-33, IL25, and TSLP was first detected in allergic and infectious diseases, most studies on alarmins focus on their role in these diseases. However, recent studies suggest that alarmins also have a broad range of effector functions in other pathological conditions, including psoriasis, multiple sclerosis, and cancer. Therefore, this review provides an update on the epitheliumderived cytokines in both allergic and non-allergic diseases. We also review the progress of clinical trials on biological agents that target the alarmins and discuss the therapeutic potential of these agents in non-allergic diseases. | - |
dc.language | 영어 | - |
dc.publisher | 대한면역학회 | - |
dc.title | Targeting the Epithelium-Derived Innate Cytokines: From Bench to Bedside | - |
dc.type | Article | - |
dc.identifier.doi | 10.4110/in.2022.22.e11 | - |
dc.citation.journaltitle | Immune Network | - |
dc.identifier.wosid | 000766737100008 | - |
dc.identifier.scopusid | 2-s2.0-85126519111 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | e11 | - |
dc.citation.volume | 22 | - |
dc.identifier.kciid | ART002817740 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Hye Young | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
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