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Myeloid cell leukemia-1 expression in cancers of the oral cavity: a scoping review
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Su‑Jung Choi | - |
dc.contributor.author | Neeti Swarup | - |
dc.contributor.author | Ji‑Ae Shin | - |
dc.contributor.author | Seong‑Doo Hong | - |
dc.contributor.author | Sung‑Dae Cho | - |
dc.date.accessioned | 2022-05-18T02:35:40Z | - |
dc.date.available | 2022-05-18T02:35:40Z | - |
dc.date.issued | 2022-05-06 | - |
dc.identifier.citation | Cancer Cell International. Vol 22(1):182 | ko_KR |
dc.identifier.issn | 1475-2867 | - |
dc.identifier.uri | https://hdl.handle.net/10371/179848 | - |
dc.description.abstract | B cell lymphoma-2 (Bcl-2) family members play important roles in cell survival as well as cell death. The role of myeloid cell leukemia-1 (Mcl-1), an important member of the Bcl-2 family, is well established in hematopoietic malignancies. However, the association between Mcl-1 and oral cavity, cancers is not clearly defined.
A scoping review was conducted until June 30, 2021, using four major databases, PubMed, Scopus, Web of Science, and Embase. Medical subject headings keywords for Mcl-1, along with its other identifiers, and head and neck cancers (only oral cavity tumors) were used to evaluate the expression, function, molecular association, and therapeutic approach of Mcl-1 in oral cavity cancers and precancers. Mcl-1 expression was associated with the progression of oral cavity cancers. The molecular mechanism and pathways of Mcl-1 in oral cavity cancers established via experimental results have been highlighted in this review. Moreover, the various synthetic and naturally derived therapeutic agents targeting Mcl-1 have been documented. Based on our present review, Mcl-1 appears to be an effective anticancer target that can be used in the therapeutic management of oral cancers. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BMC | ko_KR |
dc.subject | Mcl-1 | - |
dc.subject | Oral cavity | - |
dc.subject | Cancer | - |
dc.subject | Agents targeting Mcl-1 | - |
dc.title | Myeloid cell leukemia-1 expression in cancers of the oral cavity: a scoping review | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | https://doi.org/10.1186/s12935-022-02603-0 | ko_KR |
dc.citation.journaltitle | Cancer Cell International | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-05-08T03:29:10Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 182 | ko_KR |
dc.citation.volume | 22 | ko_KR |
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