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Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
Cited 4 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2020-08
- Publisher
- Cell Press
- Citation
- iScience, Vol.23 No.8, p. 101386
- Abstract
- Exome and transcriptome analyses of clinically homogeneous early-stage never -smoker female patients with lung adenocarcinoma were performed to under-stand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, devel-oping a method for effective selection of rare immune checkpoint blockade re-sponders, and finding new treatment strategies.
- ISSN
- 2589-0042
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