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Short communication: Dietary bovine milk-derived exosomes improve bone health in an osteoporosis-induced mouse model
DC Field | Value | Language |
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dc.contributor.author | Yun, B. | - |
dc.contributor.author | Maburutse, B. E. | - |
dc.contributor.author | Kang, M. | - |
dc.contributor.author | Park, M. R. | - |
dc.contributor.author | Park, D. J. | - |
dc.contributor.author | Kim, Y. | - |
dc.contributor.author | Oh, S. | - |
dc.date.accessioned | 2022-06-24T00:29:35Z | - |
dc.date.available | 2022-06-24T00:29:35Z | - |
dc.date.created | 2020-10-27 | - |
dc.date.created | 2020-10-27 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | Journal of Dairy Science, Vol.103 No.9, pp.7752-7760 | - |
dc.identifier.issn | 0022-0302 | - |
dc.identifier.uri | https://hdl.handle.net/10371/183891 | - |
dc.description.abstract | Osteoporosis is a systemic skeletal disease character-ized by low bone mass and micro-architectural dete-rioration of bone tissue, with a consequent increase in bone fragility and fracture susceptibility. In an aged so-ciety with increased life expectancy, the incidence rate of osteoporosis is also rapidly increasing. Inadequate nutrition may negatively influence bone metabolism. Recently, many studies have investigated the function-ality of milk-derived exosomes, which play important roles in cell-to-cell communication. However, there are few reports of how milk-derived exosomes influence osteoblast proliferation and differentiation. Here, we determined whether bovine colostrum-derived exo-somes promote anti-osteoporosis in vitro and in vivo. Tartrate-resistant acid phosphatase & ndash;stained cells were significantly inhibited in Raw264.7 cells treated with exosomes, indicating reduced osteoclast differentiation. We induced osteoporosis in mice using glucocorticoid pellets after orally administering exosomes for 2 mo. Interestingly, the bone mineral density of exosome-fed mouse groups was significantly improved compared with the glucocorticoid-induced osteoporosis group without exosome treatment. In addition, Lactobacil-lus were decreased in the gut microbiota community of osteoporosis-induced mice, but the gut microbiota community composition was effectively restored by exo-some intake. Taken together, we propose that exosomes isolated from bovine colostrum could be a potential candidate for osteoporosis prevention, bone remodeling improvement, and inhibition of bone resorption. To our knowledge, this is the first time that a protective effect of milk exosomes against osteoporosis has been demonstrated in vivo. Our results strongly suggest that bovine colostrum exosomes might be used as a prophylaxis to prevent the onset of osteoporosis. Indeed, our results offer promising alternative strategies in the nutritional management of age-related bone complications. | - |
dc.language | 영어 | - |
dc.publisher | American Dairy Science Association | - |
dc.title | Short communication: Dietary bovine milk-derived exosomes improve bone health in an osteoporosis-induced mouse model | - |
dc.type | Article | - |
dc.identifier.doi | 10.3168/jds.2019-17501 | - |
dc.citation.journaltitle | Journal of Dairy Science | - |
dc.identifier.wosid | 000563169800009 | - |
dc.identifier.scopusid | 2-s2.0-85087768181 | - |
dc.citation.endpage | 7760 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 7752 | - |
dc.citation.volume | 103 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Y. | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | IMMUNE-RELATED MICRORNAS | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | OSTEOCLASTS | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | ABUNDANT | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordAuthor | milk-derived exosome | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | osteoclast differentiation | - |
dc.subject.keywordAuthor | microbiota | - |
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