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Validation for measurements of skeletal muscle areas using low-dose chest computed tomography
Cited 4 time in
Web of Science
Cited 4 time in Scopus
- Authors
- Issue Date
- 2022-12
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, Vol.12 No.1, p. 463
- Abstract
- Various methods were suggested to measure skeletal muscle areas (SMAs) using chest low-dose computed tomography (chest LDCT) as a substitute for SMA at 3rd lumbar vertebra level (L3-SMA). In this study, four SMAs (L1-SMA, T12-erector spinae muscle areas, chest wall muscle area at carina level, pectoralis muscle area at aortic arch level) were segmented semi-automatically in 780 individuals taking concurrent chest and abdomen LDCT for healthcare screening. Four SMAs were compared to L3-SMA and annual changes were calculated from individuals with multiple examinations (n = 101). Skeletal muscle index (SMI; SMA/height(2)) cut-off for sarcopenia was determined by lower 5th percentile of young individuals (age <= 40 years). L1-SMA showed the greatest correlation to L3-SMA (men, R-2 = 0.7920; women, R-2 = 0.7396), and the smallest annual changes (0.3300 +/- 4.7365%) among four SMAs. L1-SMI cut-offs for determining sarcopenia were 39.2cm(2)/m(2) in men, and 27.5cm(2)/m(2) in women. Forty-six men (9.5%) and ten women (3.4%) were found to have sarcopenia using L1-SMI cut-offs. In conclusion, L1-SMA could be a reasonable substitute for L3-SMA in chest LDCT. Suggested L1-SMI cut-offs for sarcopenia were 39.2cm(2)/m(2) for men and 27.5cm(2)/m(2) for women in Asian.
- ISSN
- 2045-2322
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