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Postbiotic heat-killed lactobacilli modulates on body weight associated with gut microbiota in a pig model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Sangdon | - |
dc.contributor.author | Kyoung, Hyunjin | - |
dc.contributor.author | Park, Kyeong Il | - |
dc.contributor.author | Oh, Sangnam | - |
dc.contributor.author | Song, Minho | - |
dc.contributor.author | Kim, Younghoon | - |
dc.date.accessioned | 2022-08-06T07:28:47Z | - |
dc.date.available | 2022-08-06T16:31:05Z | - |
dc.date.issued | 2022-06-29 | - |
dc.identifier.citation | AMB Express,12(1):83 | ko_KR |
dc.identifier.uri | https://doi.org/10.1186/s13568-022-01424-8 | - |
dc.identifier.uri | https://hdl.handle.net/10371/184238 | - |
dc.description.abstract | For decades, Lactobacillus has been extensively used as beneficial probiotics because it positively effects on the intestinal health of the host and has been studying its possible serve to treat obesity as well as various diseases. This research aimed to investigate the effects of heat-killed Ligilactobacillus salivarius strain 189 (HK LS 189) supplementation on anti-obesity and gut microbiota. A total of 48 pigs were fed either a basal diet or a diet supplemented with HK LS 189 for 4 weeks. The impact of HK LS 189 supplementation on the composition and function of the intestinal microbiota was revealed by 16S rRNA gene sequencing. HK LS 189 supplementation significantly decreased growth performance. Moreover, HK LS 189 supplementation altered the gut microbiota of the pigs by decreasing the proportion of Prevotella and increasing the proportion of Parabacteroides. Beta-diversity analysis showed a significant difference between the two groups. The results support the potential use of HK LS 189 for its anti-obesity effect in pigs through modulation of the gut microbiota. Furthermore, we found changes in the functional pathways of the gut microbiota. The functional pathway study indicated that metabolism and lipid metabolism differed between the two groups. Our data may contribute to understanding the potential use of postbiotic supplementation with HK LS 189 for improving the anti-obesity effects. | ko_KR |
dc.description.sponsorship | This research was supported by a National Research Foundation of Korea Grant, funded by the Korean government (MEST) (NRF-2021R1A2C3011051) and by the support of Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ0158652021) Rural Development Administration, Republic of Korea. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | Springer Open | ko_KR |
dc.subject | Heat-killed Ligilactobacillus salivarius | - |
dc.subject | Postbiotics | - |
dc.subject | gut microbiota | - |
dc.subject | Anti-obesity | - |
dc.subject | Lipid metabolism | - |
dc.title | Postbiotic heat-killed lactobacilli modulates on body weight associated with gut microbiota in a pig model | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1186/s13568-022-01424-8 | ko_KR |
dc.citation.journaltitle | AMB Express | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2022-07-03T03:14:19Z | - |
dc.citation.number | 1 | ko_KR |
dc.citation.startpage | 83 | ko_KR |
dc.citation.volume | 12 | ko_KR |
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