Browse

Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Jeon, Yoon Kyung; Chang, Kee-Hyun; Suh, Yeon-Lim; Jung, Hee Won; Park, Sung-Hye
Issue Date
2005-04-05
Publisher
Lippincott, Williams & Wilkins
Citation
J Neuropathol Exp Neurol. 2005 Mar;64(3):254-9.
Keywords
Actins/metabolismAdultAgedCentral Nervous System Neoplasms/metabolism/*pathologyFemaleGranuloma, Plasma Cell/metabolism/pathology/physiopathologyHumansImmunohistochemistry/methodsInflammation/etiology/pathologyMagnetic Resonance Imaging/methodsMaleMiddle AgedNeoplasms, Muscle Tissue/*complications/metabolism/*pathologySex FactorsStaining and Labeling/methods
Abstract
To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) of the central nervous system (CNS), we analyzed 10 cases of IMTs-CNS (8 cranial, 1 spinal, and 1 orbital). Our series of IMTs of the CNS showed a male predominance (male:female = 6:4) and a wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, they showed two patterns: isolated mass forming (n = 6) and an en plaque-like pattern (n = 4). Histopathologically, plasma cell granuloma (PCG)-like (n = 5) or fibrohistiocytic (FHC) variant (n = 5) was present. No correlation was found between the radiologic and histopathologic patterns. Spindle-shaped mesenchymal cells of IMTs expressed smooth muscle actin (SMA) in all cases. ALK expression was not found in our IMTs of the CNS. Late recurrence was found in 2 cases in different sites (20%). Pathologically, IMT-CNS could be subclassified into PCG-like and FHC. Immunostaining for SMA was found to helpfully discriminate myofibroblastic cells and to make a differential diagnosis. Although our cases did not show ALK immunoreactivity, some IMTs-CNS can recur, which suggests the neoplastic potential of these tumors. The rearrangement of the ALK gene in IMTs-CNS should be verified by an examination of more cases.
ISSN
0022-3069 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15804057

http://hdl.handle.net/10371/18428
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse