S-Space College of Medicine/School of Medicine (의과대학/대학원) Neurosurgery (신경외과학전공) Journal Papers (저널논문_신경외과학전공)
Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases
- Jeon, Yoon Kyung; Chang, Kee-Hyun; Suh, Yeon-Lim; Jung, Hee Won; Park, Sung-Hye
- Issue Date
- Lippincott, Williams & Wilkins
- J Neuropathol Exp Neurol. 2005 Mar;64(3):254-9.
- Actins/metabolism; Adult; Aged; Central Nervous System Neoplasms/metabolism/*pathology; Female; Granuloma, Plasma Cell/metabolism/pathology/physiopathology; Humans; Immunohistochemistry/methods; Inflammation/etiology/pathology; Magnetic Resonance Imaging/methods; Male; Middle Aged; Neoplasms, Muscle Tissue/*complications/metabolism/*pathology; Sex Factors; Staining and Labeling/methods
- To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) of the central nervous system (CNS), we analyzed 10 cases of IMTs-CNS (8 cranial, 1 spinal, and 1 orbital). Our series of IMTs of the CNS showed a male predominance (male:female = 6:4) and a wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, they showed two patterns: isolated mass forming (n = 6) and an en plaque-like pattern (n = 4). Histopathologically, plasma cell granuloma (PCG)-like (n = 5) or fibrohistiocytic (FHC) variant (n = 5) was present. No correlation was found between the radiologic and histopathologic patterns. Spindle-shaped mesenchymal cells of IMTs expressed smooth muscle actin (SMA) in all cases. ALK expression was not found in our IMTs of the CNS. Late recurrence was found in 2 cases in different sites (20%). Pathologically, IMT-CNS could be subclassified into PCG-like and FHC. Immunostaining for SMA was found to helpfully discriminate myofibroblastic cells and to make a differential diagnosis. Although our cases did not show ALK immunoreactivity, some IMTs-CNS can recur, which suggests the neoplastic potential of these tumors. The rearrangement of the ALK gene in IMTs-CNS should be verified by an examination of more cases.
- 0022-3069 (Print)
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