Publications
Detailed Information
Inflammatory myofibroblastic tumor of the central nervous system: clinicopathologic analysis of 10 cases
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Issue Date
- 2005-04-05
- Publisher
- Lippincott, Williams & Wilkins
- Citation
- J Neuropathol Exp Neurol. 2005 Mar;64(3):254-9.
- Keywords
- Actins/metabolism ; Adult ; Aged ; Central Nervous System Neoplasms/metabolism/*pathology ; Female ; Granuloma, Plasma Cell/metabolism/pathology/physiopathology ; Humans ; Immunohistochemistry/methods ; Inflammation/etiology/pathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasms, Muscle Tissue/*complications/metabolism/*pathology ; Sex Factors ; Staining and Labeling/methods
- Abstract
- To verify the pathologic features, anaplastic lymphoma kinase (ALK) expression and biologic behavior of inflammatory myofibroblastic tumors (IMTs) of the central nervous system (CNS), we analyzed 10 cases of IMTs-CNS (8 cranial, 1 spinal, and 1 orbital). Our series of IMTs of the CNS showed a male predominance (male:female = 6:4) and a wide age range (10-60 years; mean age, 46.7 years). Lesion location also varied, but they were basically dura-based. Radiologically, they showed two patterns: isolated mass forming (n = 6) and an en plaque-like pattern (n = 4). Histopathologically, plasma cell granuloma (PCG)-like (n = 5) or fibrohistiocytic (FHC) variant (n = 5) was present. No correlation was found between the radiologic and histopathologic patterns. Spindle-shaped mesenchymal cells of IMTs expressed smooth muscle actin (SMA) in all cases. ALK expression was not found in our IMTs of the CNS. Late recurrence was found in 2 cases in different sites (20%). Pathologically, IMT-CNS could be subclassified into PCG-like and FHC. Immunostaining for SMA was found to helpfully discriminate myofibroblastic cells and to make a differential diagnosis. Although our cases did not show ALK immunoreactivity, some IMTs-CNS can recur, which suggests the neoplastic potential of these tumors. The rearrangement of the ALK gene in IMTs-CNS should be verified by an examination of more cases.
- ISSN
- 0022-3069 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15804057
https://hdl.handle.net/10371/18428
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.